The Bears defense is ranked #5 against the pass, #22 against the run. This should be a Guerendo workout. We saw him at practice off to the side by himself with paper in hand going through some mental reps of specific plays. Shanahan will need to establish his run game and stick to it to have any chance of winning. Without CMC the onus will be on George Kittle to defeat man coverage behind the Bears loaded box to stop the run. The good news defensively for the 49ers is the overall #1 pick Caleb Williams is struggling near the bottom in QBR at 27th while Purdy is 7th. Williams has been sacked 49 times! Even without Bosa there should be opportunities for this defense to make more noise in the backfield than they have the last 2 games. If the 49ers can keep Williams from making splash plays either with his legs or off schedule they'll have a chance to win a tight game. 23-20 San Francisco!
49ers inactives: QB Josh Dobbs (3rd QB) T Trent Williams (heel) G Aaron Banks (concussion) DE Nick Bosa (hip/oblique) LB Demetrius Flannigan-Fowles CB Rock Ya-Sin RB Israel Abanikanda

